Dr. Hughes received his M.D. from Washington University in St.Louis, and completed his residency at Washington University in St. Louis as well.  He established the first "Lipid Clinic" at the University of Alabama, Birmingham in 1981. He was on the faculty at UAB from 1981 to 1987.

Dr. Hughes was on the faculty at the University of TN School of Medicine, Division of Endocrinology, for 27 years, until he retired from the University in 2014.  He continues to teach at UT on a volunteer basis.  He practiced at UTMedical Group, The MEDPLEX, and UT-Methodist from 1987 to 2014.  In 2014, he joined G2Endo.  In 2018, he opened his own practice as Hughes Endocrinology.

Dr. Hughes has trained many of the practicing endocrinologists in the Mid-South.  He is Board Certified in Internal Medicine and Endocrinology, Diabetes and Metabolism.  He lives with his wife, Sue, in Olive Branch, Mississippi.  He enjoys spending time with their four children and eight grandchildren and taking care of their horses.

Honors:  
​Member: American Diabetes Association's Cardiovascular Risk Management Faculty
"The Best Doctors in America: Midwest Region" by Woodward/White, Inc., Aiken, SC
"Who's Who in Medicine and Healthcare," New Providence, NJ
National Faculty for the Vascular Biology Working Group
Southeast Regional Lipid Advisory Board
National Diabetes Educational Initiative: National Teaching Faculty
Lipid Management in Clinical Practice (LMCP): National Teaching Faculty
Best Doctors in America 2003 to 2017